This dataset comprises cleaned, standard genetics data of the CYP1B1 gene from 1810 samples. Seven tag single nucleotide polymorphisms (SNPs), including two coding variants (L432V and N543S), were genotyped in 860 primary open angle glaucoma (POAG) cases and 898 examined normal controls. Each SNP and haplotype was assessed for association with disease.
Relevant column headings for the *.ped file are: Family ID Individual ID Father ID Mother ID Sex Affection status
Then the remainder describe genotypes at single nucleotide polymorphisms, as described in the *.map file, 2 columns per SNP
In the *.map file: Chromosome SNP name Position in centiMorgans Position in basepairs
Date coverage: 2010-01-01 - 2010-06-30 Location: Australia
Funding
A genome-wide association study in 2000 glaucoma cases with matched controls using equimoloar DNA pools